TY  - JOUR
AU  - Shehata, Moustafa A
AU  - Contreras, Julia
AU  - Martín-Hurtado, Ana
AU  - Froux, Aurane
AU  - Mohamed, Hossam Taha
AU  - El-Sherif, Ahmed A
AU  - Plaza-Menacho, Iván
AU  - Shehata, Moustafa A.
AU  - El-Sherif, Ahmed A.
PY  - 2022
DO  - 10.1016/j.jare.2022.05.004
SN  - 2090-1232
UR  - http://hdl.handle.net/20.500.12105/14792
AB  - The structural and dynamic determinants for highly selective RET kinase inhibition are poorly understood.Here we demonstrate by applying an integrated structural, computational and biochemical approach that the druggability landscape of the RET active...
LA  - eng
PB  - Elsevier
KW  - Protein kinases
KW  - Oncogene
KW  - Targeted-therapies
KW  - Structure - Function
KW  - Drug-discovery
TI  - Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.
TY  - journal article
ER  -