TY - JOUR AU - Dodd, Thomas AU - Botto, Margherita AU - Paul, Fabian AU - Lamers, Meindert H AU - Ivanov, Ivaylo AU - Fernandez-Leiro, Rafael AU - Dodd, Thomas AU - Botto, Margherita AU - Paul, Fabian AU - Lamers, Meindert H AU - Ivanov, Ivaylo AU - Fernandez-Leiro, Rafael PY - 2020 DO - 10.1038/s41467-020-19165-2 UR - http://hdl.handle.net/20.500.12105/12182 AB - Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA replication fidelity. In proofreading, mis-incorporated nucleotides are excised through the 3'-5' exonuclease activity of the DNA polymerase holoenzyme. The... LA - eng PB - Nature Publishing Group KW - Polymerization KW - DNA KW - DNA Polymerase III KW - DNA Primers KW - DNA Replication KW - DNA-Directed DNA Polymerase KW - Escherichia coli KW - Exonucleases KW - Kinetics KW - Models, Molecular KW - Protein Conformation TI - Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path. TY - journal article ER -