TY  - GEN
AU  - Gupta, Amit
AU  - Anjomani-Virmouni, Sara
AU  - Koundouros, Nikos
AU  - Dimitriadi, Maria
AU  - Choo-Wing, Rayman
AU  - Valle, Adamo
AU  - Zheng, Yuxiang
AU  - Chiu, Yu-Hsin
AU  - Agnihotri, Sameer
AU  - Zadeh, Gelareh
AU  - Asara, John M
AU  - Anastasiou, Dimitrios
AU  - Arends, Mark J
AU  - Cantley, Lewis C
AU  - Poulogiannis, George
PY  - 2017
DO  - 10.1016/j.molcel.2017.02.019
SN  - 1097-2765
UR  - http://hdl.handle.net/20.500.12105/20418
AB  - PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all human cancers, and its...
LA  - eng
PB  - Cell Press
KW  - Dose-Response Relationship, Drug
KW  - Enzyme Activation
KW  - Cell Movement
KW  - Humans
KW  - Ubiquitin-Protein Ligases
KW  - TOR Serine-Threonine Kinases
KW  - MCF-7 Cells
KW  - Protein Processing, Post-Translational
KW  - Cell Survival
KW  - Time Factors
KW  - AMP-Activated Protein Kinases
KW  - Oxidation-Reduction
KW  - Proto-Oncogene Proteins c-akt
KW  - Mice, Inbred NOD
KW  - Signal Transduction
KW  - Mice, Knockout
KW  - PTEN Phosphohydrolase
KW  - Gene Expression Regulation, Neoplastic
KW  - Tumor Burden
KW  - Oxidative Stress
KW  - Energy Metabolism
KW  - Transfection
KW  - HEK293 Cells
KW  - HCT116 Cells
KW  - Nitric Oxide
KW  - Antineoplastic Agents
KW  - Protein Kinase Inhibitors
KW  - Cell Proliferation
KW  - Neoplasms
KW  - Gene Expression Profiling
KW  - Nitric Oxide Synthase Type III
KW  - Animals
KW  - Ubiquitination
KW  - Phosphatidylinositol 3-Kinase
KW  - Mice, SCID
KW  - RNA Interference
TI  - PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation
TY  - research article
ER  -