TY  - JOUR
AU  - Park, Solip
AU  - Supek, Fran
AU  - Lehner, Ben
PY  - 2021
DO  - 10.1038/s41467-021-27242-3
UR  - http://hdl.handle.net/20.500.12105/13729
AB  - The classic two-hit model posits that both alleles of a tumor suppressor gene (TSG) must be inactivated to cause cancer. In contrast, for some oncogenes and haploinsufficient TSGs, a single genetic alteration can suffice to increase tumor fitness....
LA  - eng
PB  - Nature Publishing Group
KW  - MUTATIONS
KW  - LANDSCAPE
KW  - PATHWAYS
KW  - PATTERNS
KW  - Genes, Tumor Suppressor
KW  - Models, Genetic
KW  - Oncogenes
KW  - Alleles
KW  - Carcinogenesis
KW  - DNA Copy Number Variations
KW  - Datasets as Topic
KW  - Haploinsufficiency
KW  - Humans
KW  - Mutation
KW  - Neoplasms
TI  - Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.
TY  - journal article
ER  -