TY  - JOUR
AU  - Gómez-Aleza, Clara
AU  - Nguyen, Bastien
AU  - Yoldi, Guillermo
AU  - Ciscar, Marina
AU  - Barranco, Alexandra
AU  - Hernández-Jiménez, Enrique
AU  - Maetens, Marion
AU  - Salgado, Roberto
AU  - Zafeiroglou, Maria
AU  - Pellegrini, Pasquale
AU  - Venet, David
AU  - Garaud, Soizic
AU  - Trinidad, Eva M
AU  - Benítez, Sandra
AU  - Vuylsteke, Peter
AU  - Polastro, Laura
AU  - Wildiers, Hans
AU  - Simon, Philippe
AU  - Lindeman, Geoffrey
AU  - Larsimont, Denis
AU  - Van den Eynden, Gert
AU  - Velghe, Chloé
AU  - Rothé, Françoise
AU  - Willard-Gallo, Karen
AU  - Michiels, Stefan
AU  - Muñoz, Purificación
AU  - Walzer, Thierry
AU  - Planelles, Lourdes
AU  - Penninger, Josef
AU  - Azim, Hatem A
AU  - Loi, Sherene
AU  - Piccart, Martine
AU  - Sotiriou, Christos
AU  - González-Suárez, Eva
PY  - 2020
DO  - 10.1038/s41467-020-20138-8
UR  - http://hdl.handle.net/20.500.12105/12178
AB  - Most breast cancers exhibit low immune infiltration and are unresponsive to immunotherapy. We hypothesized that inhibition of the receptor activator of nuclear factor-κB (RANK) signaling pathway may enhance immune activation. Here we report that loss...
LA  - eng
PB  - Nature Publishing Group
KW  - Immunity
KW  - Signal Transduction
KW  - Adult
KW  - Animals
KW  - Breast Neoplasms
KW  - CD8-Positive T-Lymphocytes
KW  - Cell Line, Tumor
KW  - Chemokines
KW  - Denosumab
KW  - Female
KW  - Humans
KW  - Immunosuppression
KW  - Immunotherapy
KW  - Inflammation Mediators
KW  - Lymphocytes, Tumor-Infiltrating
KW  - Mice, Inbred C57BL
KW  - Middle Aged
KW  - Models, Biological
KW  - Myeloid Cells
KW  - Neoplasm Staging
KW  - Neutrophils
KW  - RANK Ligand
KW  - Receptor Activator of Nuclear Factor-kappa B
TI  - Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.
TY  - journal article
ER  -