TY  - JOUR
AU  - Schoppy, David W
AU  - Ragland, Ryan L
AU  - Gilad, Oren
AU  - Shastri, Nishita
AU  - Peters, Ashley A
AU  - Murga, Matilde
AU  - Fernandez-Capetillo, Oscar
AU  - Diehl, J Alan
AU  - Brown, Eric J
PY  - 2012
DO  - 10.1172/JCI58928
UR  - http://hdl.handle.net/20.500.12105/19189
AB  - Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have indicated that each of these genetic...
LA  - eng
PB  - American Society for Clinical Investigation (ASCI)
KW  - Mutation
KW  - Oncogenes
KW  - Animals
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - Cell Cycle Proteins
KW  - DNA Damage
KW  - Fibrosarcoma
KW  - Genes, p53
KW  - Genes, ras
KW  - Homeostasis
KW  - Humans
KW  - Leukemia, Myeloid, Acute
KW  - Mice
KW  - Mice, 129 Strain
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mice, Nude
KW  - Mice, Transgenic
KW  - Neoplasms, Experimental
KW  - Protein Serine-Threonine Kinases
KW  - RNA, Messenger
KW  - Stress, Physiological
TI  - Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.
TY  - journal article
ER  -