TY - JOUR AU - Theurillat, Jean-Philippe AU - Metzler, Stefan Christian AU - Henzi, Nico AU - Djouder, Nabil AU - Helbling, Marianne AU - Zimmermann, Anna-Kathrin AU - Jacob, Francis AU - Soltermann, Alex AU - Caduff, Rosmarie AU - Heinzelmann-Schwarz, Viola AU - Moch, Holger AU - Krek, Wilhelm PY - 2011 DO - 10.1016/j.ccr.2011.01.019 UR - http://hdl.handle.net/20.500.12105/17543 AB - Abrogation of negative feedback control represents a fundamental requirement for aberrantly activated signaling pathways to promote malignant transformation and resistance to therapy. Here we identify URI, which encodes a mitochondrial inhibitor of... LA - eng PB - Elsevier KW - Gene Amplification KW - Animals KW - Cell Line, Tumor KW - Cell Survival KW - Female KW - Gene Expression Regulation, Neoplastic KW - HeLa Cells KW - Humans KW - Immunoblotting KW - Immunohistochemistry KW - In Situ Hybridization, Fluorescence TI - URI is an oncogene amplified in ovarian cancer cells and is required for their survival. TY - journal article ER -