TY  - JOUR
AU  - Quirós, Pedro M
AU  - Español, Yaiza
AU  - Acin-Perez, Rebeca
AU  - Rodríguez, Francisco
AU  - Bárcena, Clea
AU  - Watanabe, Kenta
AU  - Calvo, Enrique
AU  - Loureiro, Marta
AU  - Fernández-García, M Soledad
AU  - Fueyo, Antonio
AU  - Vazquez, Jesus
AU  - Enriquez, Jose Antonio
AU  - López-Otín, Carlos
PY  - 2014
DO  - 10.1016/j.celrep.2014.06.018
SN  - 22111247
UR  - http://hdl.handle.net/20.500.12105/7349
AB  - We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality, whereas its haploinsufficiency protects against colorectal and skin...
LA  - eng
PB  - Elsevier
KW  - ATP-Dependent Proteases
KW  - Animals
KW  - Cell Proliferation
KW  - Cellular Senescence
KW  - Colorectal Neoplasms
KW  - Gene Deletion
KW  - HCT116 Cells
KW  - HEK293 Cells
KW  - Haploinsufficiency
KW  - Homozygote
KW  - Humans
KW  - Melanoma
KW  - Mice
KW  - Mitochondria
KW  - Skin Neoplasms
KW  - Oxidative Phosphorylation
TI  - ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity
TY  - journal article
ER  -