TY - JOUR AU - Martinez-Martinez, Sara AU - Lozano-Vidal, Noelia AU - Lopez-Maderuelo, Dolores AU - Jimenez-Borreguero, Luis J. AU - Armesilla, Angel Luis AU - Redondo, Juan Miguel PY - 2019 DO - 10.1111/febs.14718 SN - 1742-464X UR - http://hdl.handle.net/20.500.12105/9850 AB - Previous studies have demonstrated that activation of calcineurin induces pathological cardiac hypertrophy (CH). In these studies, loss-of-function was mostly achieved by systemic administration of the calcineurin inhibitor cyclosporin A. The lack of... LA - eng PB - Federation of European Biochemical Societies (FEBS) KW - Angiotensin II KW - Cyclosporin A KW - Heart KW - Pro-fibrotic genes KW - Angiotensin II KW - Animals KW - Calcineurin KW - Cardiomegaly KW - Disease Progression KW - Fibrosis KW - Gene Expression Profiling KW - Mice KW - Mice, Knockout KW - Myocytes, Cardiac KW - Signal Transduction KW - Vasoconstrictor Agents TI - Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice TY - journal article ER -