TY - JOUR AU - McGinley, Aoife M AU - Sutton, Caroline E AU - Edwards, Sarah C AU - Leane, Charlotte M AU - DeCourcey, Joseph AU - Teijeiro, Ana AU - Hamilton, John A AU - Boon, Louis AU - Djouder, Nabil AU - Mills, Kingston H G PY - 2020 DO - 10.1016/j.immuni.2020.01.002 UR - http://hdl.handle.net/20.500.12105/17561 AB - Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that... LA - eng PB - Cell Press KW - Animals KW - Autoantigens KW - Autoimmunity KW - Central Nervous System KW - Encephalomyelitis, Autoimmune, Experimental KW - Interleukin-17 KW - Interleukin-1beta KW - Interleukin-23 KW - Intraepithelial Lymphocytes KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Monocytes KW - Myeloid Cells KW - Neutrophils KW - Th17 Cells TI - Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. TY - journal article ER -