TY - JOUR AU - Nitschke, Katja AU - Schmidt, Julia AU - Timm, Jörg AU - Viazov, Sergei AU - Kuntzen, Thomas AU - Kim, Arthur Y AU - Lauer, Georg M AU - Allen, Todd M AU - Gaudieri, Silvana AU - Rauch, Andri AU - Lange, Christian M AU - Sarrazin, Christoph AU - Eiermann, Thomas AU - Sidney, John AU - Sette, Alessandro AU - Thimme, Robert AU - Neumann-Haefelin, Christoph AU - Barriga, Alejandro AU - Lopez, Daniel PY - 2014 DO - 10.1016/j.jhep.2013.08.009 UR - http://hdl.handle.net/20.500.12105/10512 AB - HLA-B*27 is associated with spontaneous HCV genotype 1 clearance. HLA-B*27-restricted CD8+ T cells target three NS5B epitopes. Two of these epitopes are dominantly targeted in the majority of HLA-B*27+ patients. In chronic infection, viral escape... LA - eng PB - Elsevier KW - CD8-Positive T-Lymphocytes KW - Epitopes, T-Lymphocyte KW - HLA-B27 Antigen KW - Hepacivirus KW - Humans KW - Viral Nonstructural Proteins TI - HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. TY - journal article ER -