TY  - JOUR
AU  - Hill, Richard
AU  - Kalathur, Ravi Kiran Reddy
AU  - Callejas, Sergio
AU  - Colaço, Laura
AU  - Brandão, Ricardo
AU  - Serelde, Beatriz
AU  - Cebriá, Antonio
AU  - Blanco-Aparicio, Carmen
AU  - Pastor Fernandez, Joaquin
AU  - Futschik, Matthias
AU  - Dopazo, Ana
AU  - Link, Wolfgang
PY  - 2014
DO  - 10.1186/s13058-014-0482-y
SN  - 1465-542X
UR  - http://hdl.handle.net/20.500.12105/7524
AB  - INTRODUCTION: The activation of the phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is one the most frequent genetic events in breast cancer, consequently the development of PI3K inhibitors has attracted much attention. Here we evaluate the...
LA  - eng
PB  - BioMed Central (BMC)
KW  - Cell Cycle Checkpoints
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Computer Simulation
KW  - Female
KW  - Forkhead Transcription Factors
KW  - HCT116 Cells
KW  - Humans
KW  - In Vitro Techniques
KW  - MCF-7 Cells
KW  - Phosphatidylinositol 3-Kinase
KW  - Proto-Oncogene Proteins c-akt
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Real-Time Polymerase Chain Reaction
KW  - Signal Transduction
KW  - Adenocarcinoma
KW  - Breast Neoplasms
TI  - A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes
TY  - journal article
ER  -