TY - GEN AU - Rodriguez-Arevalo, Sergio AU - Bagan, Andrea AU - Grinan-Ferre, Christian AU - Vasilopoulou, Foteini AU - Pallas, Merce AU - Brocos-Mosquera, Iria AU - Callado, Luis F AU - Isabel Loza, M AU - Martinez, Anton L AU - Brea, Jose AU - Perez, Belen AU - Molins, Elies AU - de Jonghe, Steven AU - Daelemans, Dirk AU - Radan, Milica AU - Djikic, Teodora AU - Nikolic, Katarina AU - Hernández-Hernández, Elena AU - García-Fuster, M Julia AU - Garcia-Sevilla, Jesus A AU - Escolano, Carmen PY - 2021 DO - 10.1016/j.ejmech.2021.113540 SN - 0223-5234 UR - https://hdl.handle.net/20.500.12105/23190 AB - Recent findings unveil the pharmacological modulation of imidazoline I-2 receptors (I-2-IR) as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we report the chemical characterization, three-dimensional quantitative... LA - eng PB - Elsevier KW - Imidazoline I-2 receptors KW - Imidazoline I-2 receptor ligands KW - Neuroprotection KW - 5xFAD KW - Benzofuranyl-2-imidazoles KW - Oxidative stress KW - Oxidative Stress KW - Alzheimer Disease KW - Dose-Response Relationship, Drug KW - Molecular Structure KW - Benzofurans KW - Humans KW - Cell Line, Tumor KW - Ligands KW - Male KW - Apoptosis KW - Structure-Activity Relationship KW - Animals KW - Imidazoles KW - Imidazoline Receptors KW - Mice TI - Benzofuranyl-2-imidazoles as imidazoline I-2 receptor ligands for Alzheimer's disease TY - research article ER -