TY  - JOUR
AU  - Apellániz-Ruiz, María
AU  - Lee, Mi-Young
AU  - Sánchez-Barroso, Lara
AU  - Gutiérrez-Gutiérrez, Gerardo
AU  - Calvo, Isabel
AU  - García-Estévez, Laura
AU  - Sereno, María
AU  - García-Donás, Jesús
AU  - Castelo, Beatriz
AU  - Guerra, Eva
AU  - Leandro-García, Luis J
AU  - Cascón, Alberto
AU  - Johansson, Inger
AU  - Robledo Batanero, Mercedes
AU  - Ingelman-Sundberg, Magnus
AU  - Rodriguez Antona, Cristina
PY  - 2015
DO  - 10.1158/1078-0432.CCR-14-1758
UR  - http://hdl.handle.net/20.500.12105/17503
AB  - PURPOSEPaclitaxel, a widely used chemotherapeutic drug, can cause peripheral neuropathies leading to dose reductions and treatment suspensions and decreasing the quality of life of patients. It has been suggested that genetic variants altering...
LA  - eng
PB  - American Association for Cancer Research (AACR)
KW  - Adult
KW  - Aged
KW  - Amino Acid Sequence
KW  - Antineoplastic Agents, Phytogenic
KW  - Base Sequence
KW  - Breast Neoplasms
KW  - Cytochrome P-450 CYP3A
KW  - Enzyme Stability
KW  - Exome
KW  - Female
KW  - HEK293 Cells
KW  - Humans
KW  - Middle Aged
KW  - Molecular Sequence Data
KW  - Paclitaxel
KW  - Peripheral Nervous System Diseases
KW  - Sequence Analysis, DNA
TI  - Whole-exome sequencing reveals defective CYP3A4 variants predictive of paclitaxel dose-limiting neuropathy.
TY  - journal article
ER  -