TY - GEN AU - Zarich-Dimitrievich, Natasha AU - Anta, Begoña AU - Fernández-Medarde, Alberto AU - Ballester, Alicia AU - de Lucas, Maria Pilar AU - Camara, Ana Belen AU - Anta-Felez, Berta AU - Oliva-Martinez, Jose Luis AU - Rojas-Cabañeros, Jose Maria AU - Santos, Eugenio PY - 2019 DO - 10.1038/s41389-018-0111-1 SN - 2157-9024 UR - http://hdl.handle.net/20.500.12105/7441 AB - Sos1 is an universal, widely expressed Ras guanine nucleotide-exchange factor (RasGEF) in eukaryotic cells. Its N-terminal HD motif is known to be involved in allosteric regulation of Sos1 GEF activity through intramolecular interaction with the... LA - eng PB - Nature Publishing Group TI - The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein TY - research article ER -