TY - GEN AU - Linder, Samantha J AU - Bernasocchi, Tiziano AU - Martínez-Pastor, Bárbara AU - Sullivan, Kelly D AU - Galbraith, Matthew D AU - Lewis, Caroline A AU - Ferrer, Christina M AU - Boon, Ruben AU - Silveira, Giorgia G AU - Cho, Hyo Min AU - Vidoudez, Charles AU - Shroff, Stuti AU - Oliveira-Costa, Joao P AU - Ross, Kenneth N AU - Massri, Rami AU - Matoba, Yusuke AU - Kim, Eugene AU - Rueda, Bo R AU - Stott, Shannon L AU - Gottlieb, Eyal AU - Espinosa, Joaquin M AU - Mostoslavsky, Raul PY - 2023 UR - https://hdl.handle.net/20.500.12105/26231 AB - Glutamine is a critical metabolite for rapidly proliferating cells as it is used for the synthesis of key metabolites necessary for cell growth and proliferation. Glutamine metabolism has been proposed as a therapeutic target in cancer and several... LA - eng PB - Nature Publishing Group KW - AMINO-ACID KW - TUMORS KW - SYNTHETASE KW - VULNERABILITY KW - ADAPTATION KW - ASPARAGINE KW - DEFICIENCY KW - APOPTOSIS KW - PLAYS KW - IMAGE TI - Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells. TY - research article ER -