TY  - GEN
AU  - Janssen, Kobe
AU  - Claes, Filip
AU  - Van de Velde, Dido
AU  - Wehbi, Vanessa L
AU  - Houben, Bert
AU  - Lampi, Yulia
AU  - Nys, Mieke
AU  - Khodaparast, Laleh
AU  - Khodaparast, Ladan
AU  - Louros, Nikolaos
AU  - van der Kant, Rob
AU  - Verniers, Joffre
AU  - Garcia, Teresa
AU  - Ramakers, Meine
AU  - Konstantoulea, Katerina
AU  - Maragkou, Katerina
AU  - Duran-Romaña, Ramon
AU  - Musteanu, Mónica
AU  - Barbacid, Mariano
AU  - Scorneaux, Bernard
AU  - Beirnaert, Els
AU  - Schymkowitz, Joost
AU  - Rousseau, Frederic
PY  - 2023
UR  - https://hdl.handle.net/20.500.12105/26789
AB  - Mutant KRAS is a major driver of oncogenesis in a multitude of cancers but remains a challenging target for classical small molecule drugs, motivating the exploration of alternative approaches. Here, we show that aggregation-prone regions (APRs) in...
LA  - eng
PB  - NATL ACAD SCIENCES
KW  - KRAS
KW  - oncogene
KW  - peptide
KW  - protein aggregation
KW  - protein folding
TI  - Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein.
TY  - research article
ER  -