TY - JOUR AU - Ha, Kyungsoo AU - Ma, Chengxian AU - Lin, Han AU - Tang, Lichun AU - Lian, Zhusheng AU - Zhao, Fang AU - Li, Ju-Mei AU - Zhen, Bei AU - Pei, Huadong AU - Han, Suxia AU - Malumbres Martinez, Marcos AU - Jin, Jianping AU - Chen, Huan AU - Zhao, Yongxiang AU - Zhu, Qing AU - Zhang, Pumin PY - 2017 DO - 10.1038/ncomms15751 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/6840 AB - Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). While HDR can only occur in S/G2, NHEJ can happen in all cell cycle phases (except mitosis). How then is... LA - eng PB - Nature Publishing Group KW - Anaphase-Promoting Complex-Cyclosome KW - Animals KW - Cell Line KW - DNA Breaks, Double-Stranded KW - DNA Repair KW - Genomic Instability KW - HEK293 Cells KW - HeLa Cells KW - Humans KW - Mice KW - Models, Genetic KW - Signal Transduction KW - Ubiquitin KW - DNA Damage TI - The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites TY - journal article ER -