TY - JOUR AU - Serra, Helena AU - Chivite, Iñigo AU - Angulo-Urarte, Ana AU - Soler, Adriana AU - Sutherland, James D AU - Arruabarrena-Aristorena, Amaia AU - Ragab, Anan AU - Lim, Radiance AU - Malumbres Martinez, Marcos AU - Fruttiger, Marcus AU - Potente, Michael AU - Serrano Marugan, Manuel AU - Fabra, Àngels AU - Viñals, Francesc AU - Casanovas, Oriol AU - Pandolfi, Pier Paolo AU - Bigas, Anna AU - Carracedo, Arkaitz AU - Gerhardt, Holger AU - Graupera, Mariona PY - 2015 DO - 10.1038/ncomms8935 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/10008 AB - Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in stalk cells leads to proliferation arrest via an unknown mechanism. By using gain- and... LA - eng KW - Anaphase-Promoting Complex-Cyclosome KW - Animals KW - Cdh1 Proteins KW - Cell Proliferation KW - Endothelial Cells KW - Fluorescent Antibody Technique KW - Immunoblotting KW - Mice KW - Neovascularization, Physiologic KW - PTEN Phosphohydrolase KW - Polymerase Chain Reaction KW - RNA, Messenger KW - Receptors, Notch TI - PTEN mediates Notch-dependent stalk cell arrest in angiogenesis TY - journal article ER -