TY  - GEN
AU  - de Cubas, Aguirre A
AU  - Korpershoek, Esther
AU  - Inglada-Pérez, Lucia
AU  - Letouzé, Eric
AU  - Currás-Freixes, Maria
AU  - Fernández, Agustin F
AU  - Comino-Méndez, Iñaki
AU  - Schiavi, Francesca
AU  - Mancikova, Veronika
AU  - Eisenhofer, Graeme
AU  - Mannelli, Massimo
AU  - Opocher, Guiseppe
AU  - Timmers, Henri
AU  - Beuschlein, Felix
AU  - de Krijger, Ronald
AU  - Cascon Soriano, Alberto
AU  - Rodríguez-Antona, Cristina
AU  - Fraga, Mario F
AU  - Favier, Judith
AU  - Gimenez-Roqueplo, Anne-Paule
AU  - Robledo Batanero, Mercedes
PY  - 2015
UR  - https://hdl.handle.net/20.500.12105/26066
AB  - Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, associated with highly variable postoperative evolution. The scarcity of reliable PPGL prognostic markers continues to complicate patient management. In this study, we explored...
AB  - We retrospectively investigated DNA methylation patterns in PPGL with and without metastases using high-throughput DNA methylation profiling data (Illumina 27K) from two large, well-characterized discovery (n = 123; 24 metastatic) and primary...
AB  - Of the initial 86 candidate CpGs, we successfully replicated 52 (47 genes), associated with metastatic PPGL. Of these, 48 CpGs showed significant associations with time to progression even after correcting for SDHB genotype, suggesting their value as...
AB  - This is the first large-scale study of DNA methylation in metastatic PPGL that identifies and validates prognostic markers, which could be used for stratifying patients according to risk of developing metastasis. Of the three CpGs selected for further...
LA  - eng
PB  - Amercican Association for Cancer Research
KW  - MALIGNANT PHEOCHROMOCYTOMAS
KW  - MUTATIONS
KW  - EXPRESSION
KW  - COMPLEX
KW  - PROLIFERATION
KW  - TRANSCRIPTION
KW  - ELONGATION
KW  - INHIBITORS
KW  - RECEPTORS
KW  - PHEMOTYPE
TI  - DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers.
TY  - research article
ER  -