TY  - JOUR
AU  - Flach, Johanna
AU  - Bakker, Sietske T
AU  - Mohrin, Mary
AU  - Conroy, Pauline C
AU  - Pietras, Eric M
AU  - Reynaud, Damien
AU  - Alvarez, Silvia
AU  - Diolaiti, Morgan E
AU  - Ugarte, Fernando
AU  - Forsberg, E Camilla
AU  - Le Beau, Michelle M
AU  - Stohr, Bradley A
AU  - Mendez, Juan
AU  - Morrison, Ciaran G
AU  - Passegué, Emmanuelle
PY  - 2014
DO  - 10.1038/nature13619
UR  - http://hdl.handle.net/20.500.12105/17954
AB  - Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age. Paradoxically, although HSCs numerically expand with age, their functional activity declines over time, resulting in degraded blood...
LA  - eng
PB  - Nature Publishing Group
KW  - Stress, Physiological
KW  - Animals
KW  - Cell Proliferation
KW  - Cellular Senescence
KW  - DNA Damage
KW  - DNA Replication
KW  - DNA, Ribosomal
KW  - Female
KW  - Gene Expression Regulation
KW  - Hematopoietic Stem Cells
KW  - Histones
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Minichromosome Maintenance Proteins
TI  - Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
TY  - journal article
ER  -