TY - GEN AU - García-Cosío, Borja AU - Jahn, Andreas AU - Iglesias, Amanda AU - Shafiek, Hanaa AU - Busquets, Xavier AU - Agusti, Alvar PY - 2015 DO - 10.1186/s12890-015-0155-3 SN - 1471-2466 UR - http://hdl.handle.net/20.500.12105/20163 AB - Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance. Haemophilus influenzae frequently... LA - eng PB - BioMed Central (BMC) KW - COPD exacerbation KW - Glucocorticoids KW - Colonization KW - Histone deacetylase KW - Nuclear Factor-kappa B KW - Theophylline KW - Glucocorticoids KW - Aged KW - Case-Control Studies KW - Blotting, Western KW - Adult KW - In Vitro Techniques KW - Pulmonary Disease, Chronic Obstructive KW - Humans KW - Smoking KW - Histone Deacetylases KW - Inflammation KW - Theophylline KW - Cell Line KW - Bronchodilator Agents KW - Middle Aged KW - Male KW - Cytokines KW - NF-kappa B KW - Female KW - Haemophilus Infections KW - Haemophilus influenzae KW - Macrophages, Alveolar KW - Respiratory Tract Infections KW - Dexamethasone TI - Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD TY - research article ER -