TY  - GEN
AU  - Cortegano, Isabel
AU  - Rodriguez-Garcia, Mercedes
AU  - Martín, Isabel
AU  - Prado-Zamora, Maria Carmen
AU  - Ruiz, Carolina
AU  - Hortigüela, Rafael
AU  - Alia, Mario
AU  - Vilar, Marçal
AU  - Mira, Helena
AU  - Cano, Eva
AU  - Dominguez-Rodriguez, Mercedes
AU  - Andres, Belen de
AU  - Gaspar, Maria Luisa
PY  - 2017
DO  - 10.1038/cddis.2017.351
SN  - 2041-4889
UR  - http://hdl.handle.net/20.500.12105/7189
AB  - Aging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of...
LA  - eng
PB  - Nature Publishing Group
KW  - Aging
KW  - Animals
KW  - Antigens, CD
KW  - B-Lymphocytes
KW  - Cell Death
KW  - Cell Proliferation
KW  - Gene Expression Regulation, Developmental
KW  - IgG Deficiency
KW  - Immunity, Humoral
KW  - Immunity, Innate
KW  - Immunoglobulin D
KW  - Immunoglobulin A
KW  - Immunoglobulin Heavy Chains
KW  - Immunoglobulin M
KW  - Immunologic Memory
KW  - Lipopolysaccharides
KW  - Mice, Inbred BALB
KW  - Mice, Transgenic
KW  - Primary Cell Culture
KW  - Signal Transduction
KW  - Spleen
KW  - T-Lymphocytes, Helper-Inducer
TI  - Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses
TY  - research article
ER  -