TY  - GEN
AU  - Ortega-Molina, Ana
AU  - Lebrero-Fernández, Cristina
AU  - Sanz, Alba
AU  - Deleyto-Seldas, Nerea
AU  - Plata-Gómez, Ana Belén
AU  - Menéndez, Camino
AU  - Graña-Castro, Osvaldo
AU  - Caleiras, Eduardo
AU  - Efeyan, Alejo
PY  - 2021
UR  - https://hdl.handle.net/20.500.12105/26225
AB  - B lymphocytes are exquisitely sensitive to fluctuations in nutrient signaling by the Rag GTPases, and 15% of follicular lymphomas (FLs) harbor activating mutations in RRAGC. Hence, a potential therapeutic approach against malignant B cells is to...
LA  - eng
PB  - Cell Press
KW  - B cell lymphoma
KW  - RRAGC
KW  - Rag GTPase
KW  - aging
KW  - cell growth
KW  - germinal center
KW  - longevity
KW  - lymphocytes
KW  - mTOR
KW  - nutrient signaling
TI  - Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.
TY  - research article
ER  -