TY  - GEN
AU  - Bermejo, Mercedes
AU  - Lopez-Huertas, Maria Rosa
AU  - García-Pérez, Javier
AU  - Climent, Núria
AU  - Descours, Benjamin
AU  - Ambrosioni, Juan
AU  - Mateos, Elena
AU  - Rodriguez‑Mora, Sara
AU  - Rus-Bercial, Lucía
AU  - Benkirane, Monsef
AU  - Miró, José María
AU  - Plana, Montserrat
AU  - Alcamí, José
AU  - Coiras, Mayte
PY  - 2016
DO  - 10.1016/j.bcp.2016.02.002
SN  - 0006-2952
UR  - http://hdl.handle.net/20.500.12105/10303
AB  - Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir seeding and T-cell destruction. During T-cell activation, the antiviral effect of the innate factor SAMHD1 is neutralized through phosphorylation at T592,...
LA  - eng
PB  - Elsevier
KW  - CD4+ T lymphocytes
KW  - Chronic myeloid leukemia
KW  - Dasatinib
KW  - HIV-1 reservoir
KW  - SAMHD1
KW  - Adult
KW  - Anti-HIV Agents
KW  - Antineoplastic Agents
KW  - CD4-Positive T-Lymphocytes
KW  - Cell Proliferation
KW  - Dasatinib
KW  - Female
KW  - Gene Expression Regulation
KW  - HIV Infections
KW  - HIV-1
KW  - Host-Pathogen Interactions
KW  - Humans
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - Lymphocyte Activation
KW  - Male
KW  - Monomeric GTP-Binding Proteins
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
TI  - Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells
TY  - research article
ER  -