TY  - JOUR
AU  - Bird, Thomas G
AU  - Müller, Miryam
AU  - Boulter, Luke
AU  - Vincent, David F
AU  - Ridgway, Rachel A
AU  - Lopez-Guadamillas, Elena
AU  - Lu, Wei-Yu
AU  - Jamieson, Thomas
AU  - Govaere, Olivier
AU  - Campbell, Andrew D
AU  - Ferreira-Gonzalez, Sofía
AU  - Cole, Alicia M
AU  - Hay, Trevor
AU  - Simpson, Kenneth J
AU  - Clark, William
AU  - Hedley, Ann
AU  - Clarke, Mairi
AU  - Gentaz, Pauline
AU  - Nixon, Colin
AU  - Bryce, Steven
AU  - Kiourtis, Christos
AU  - Sprangers, Joep
AU  - Nibbs, Robert J B
AU  - Van Rooijen, Nico
AU  - Bartholin, Laurent
AU  - McGreal, Steven R
AU  - Apte, Udayan
AU  - Barry, Simon T
AU  - Iredale, John P
AU  - Clarke, Alan R
AU  - Serrano, Manuel
AU  - Roskams, Tania A
AU  - Sansom, Owen J
AU  - Forbes, Stuart J
PY  - 2018
DO  - 10.1126/scitranslmed.aan1230
UR  - http://hdl.handle.net/20.500.12105/18862
AB  - Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy. However, after acute severe injury, such as acetaminophen poisoning, effective regeneration may fail. We investigated how senescence may underlie this...
LA  - eng
PB  - American Association for the Advancement of Science (AAAS)
KW  - Cellular Senescence
KW  - Liver Regeneration
KW  - Paracrine Communication
KW  - Animals
KW  - Cyclin-Dependent Kinase Inhibitor p21
KW  - Disease Models, Animal
KW  - Hepatocytes
KW  - Humans
KW  - Liver
KW  - Macrophages
KW  - Male
KW  - Mice, Inbred C57BL
KW  - Necrosis
KW  - Signal Transduction
KW  - Transforming Growth Factor beta
TI  - TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
TY  - journal article
ER  -