TY - JOUR AU - Pascual-García, Mónica AU - Bonfill-Teixidor, Ester AU - Planas-Rigol, Ester AU - Rubio-Perez, Carlota AU - Iurlaro, Raffaella AU - Arias, Alexandra AU - Cuartas, Isabel AU - Sala-Hojman, Ada AU - Escudero, Laura AU - Martínez-Ricarte, Francisco AU - Huber-Ruano, Isabel AU - Nuciforo, Paolo AU - Pedrosa, Leire AU - Marques, Carolina AU - Braña, Irene AU - Garralda, Elena AU - Vieito, María AU - Squatrito, Massimo AU - Pineda, Estela AU - Graus, Francesc AU - Espejo, Carmen AU - Sahuquillo, Juan AU - Tabernero, Josep AU - Seoane, Joan PY - 2019 DO - 10.1038/s41467-019-10369-9 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/8322 AB - Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the... LA - eng PB - Nature Publishing Group KW - Animals KW - Antibodies, Neutralizing KW - CD8-Positive T-Lymphocytes KW - Chemokine CCL2 KW - Chemokine CXCL9 KW - Epigenesis, Genetic KW - Humans KW - Immunologic Memory KW - Leukemia Inhibitory Factor KW - Lymphocytes, Tumor-Infiltrating KW - Macrophages KW - Mice, Inbred C57BL KW - Mice, SCID KW - Neoplasm Transplantation KW - Neoplasms KW - Programmed Cell Death 1 Receptor KW - Tumor Microenvironment TI - LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy TY - journal article ER -