TY - JOUR AU - Hellner, Karin AU - Miranda, Fabrizio AU - Fotso Chedom, Donatien AU - Herrero-Gonzalez, Sandra AU - Hayden, Daniel M AU - Tearle, Rick AU - Artibani, Mara AU - KaramiNejadRanjbar, Mohammad AU - Williams, Ruth AU - Gaitskell, Kezia AU - Elorbany, Samar AU - Xu, Ruoyan AU - Laios, Alex AU - Buiga, Petronela AU - Ahmed, Karim AU - Dhar, Sunanda AU - Zhang, Rebecca Yu AU - Campo, Leticia AU - Myers, Kevin A AU - Lozano, María AU - Ruiz-Miró, María AU - Gatius, Sónia AU - Mota, Alba AU - Moreno-Bueno, Gema AU - Matias-Guiu, Xavier AU - Benitez, Javier AU - Witty, Lorna AU - McVean, Gil AU - Leedham, Simon AU - Tomlinson, Ian AU - Drmanac, Radoje AU - Cazier, Jean-Baptiste AU - Klein, Robert AU - Dunne, Kevin AU - Bast, Robert C AU - Kennedy, Stephen H AU - Hassan, Bassim AU - Lise, Stefano AU - Garcia, María José AU - Peters, Brock A AU - Yau, Christopher AU - Sauka-Spengler, Tatjana AU - Ahmed, Ahmed Ashour PY - 2016 DO - 10.1016/j.ebiom.2016.06.048 SN - 23523964 UR - http://hdl.handle.net/20.500.12105/8535 AB - Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify early driver mutations in... LA - eng PB - Elsevier KW - BRCA mutations KW - Fallopian tube KW - Ovarian cancer KW - Precancer KW - SOX2 KW - Screening KW - Adult KW - Aged KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - Cell Differentiation KW - Cell Line, Tumor KW - Drug Resistance, Neoplasm KW - Fallopian Tubes KW - Female KW - Genes, BRCA1 KW - Genes, BRCA2 KW - High-Throughput Nucleotide Sequencing KW - Humans KW - Image-Guided Biopsy KW - Laparoscopy KW - Middle Aged KW - Models, Biological KW - Mutation KW - Neoplasm Staging KW - Neoplastic Stem Cells KW - Ovarian Neoplasms KW - Regulatory Sequences, Nucleic Acid KW - SOXB1 Transcription Factors KW - Gene Expression KW - Precancerous Conditions TI - Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies TY - journal article ER -