TY - JOUR AU - Ma, Feng AU - Liu, Su-Yang AU - Razani, Bahram AU - Arora, Neda AU - Li, Bing AU - Kagechika, Hiroyuki AU - Tontonoz, Peter AU - Núñez, Vanessa AU - Ricote, Mercedes AU - Cheng, Genhong PY - 2014 DO - 10.1038/ncomms6494 UR - http://hdl.handle.net/20.500.12105/15152 AB - The retinoid X receptor α (RXRα), a key nuclear receptor in metabolic processes, is downregulated during host antiviral response. However, the roles of RXRα in host antiviral response are unknown. Here we show that RXRα overexpression or ligand... LA - eng PB - Nature Publishing Group KW - Active Transport, Cell Nucleus KW - Animals KW - Cell Line KW - Down-Regulation KW - Fatty Acids, Unsaturated KW - HEK293 Cells KW - Herpes Simplex KW - Herpesvirus 1, Human KW - Humans KW - Interferon-beta KW - Ligands KW - Macrophages KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Poly I-C KW - RNA Interference KW - RNA, Small Interfering KW - Retinoid X Receptor alpha KW - Tetrahydronaphthalenes KW - Vesicular Stomatitis KW - Vesicular stomatitis Indiana virus KW - Viral Plaque Assay KW - beta Catenin TI - Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon. TY - journal article ER -