TY  - GEN
AU  - Sainz, Bruno
AU  - Alcala, Sonia
AU  - Garcia, Elena
AU  - Sanchez-Ripoll, Yolanda
AU  - Azevedo, Maria M
AU  - Cioffi, Michele
AU  - Tatari, Marianthi
AU  - Miranda-Lorenzo, Irene
AU  - Hidalgo, Manuel
AU  - Gomez-Lopez, Gonzalo
AU  - Cañamero, Marta
AU  - Erkan, Mert
AU  - Kleeff, Jörg
AU  - García-Silva, Susana
AU  - Sancho, Patricia
AU  - Hermann, Patrick C
AU  - Heeschen, Christopher
PY  - 2015
UR  - https://hdl.handle.net/20.500.12105/27250
AB  - The tumour stroma/microenvironment not only provides structural support for tumour development, but more importantly it provides cues to cancer stem cells (CSCs) that regulate their self-renewal and metastatic potential. This is certainly true for...
AB  - Microarray analyses, tumour microarray immunohistochemical assays, in vitro co-culture experiments, recombinant protein treatment approaches and in vivo intervention studies were performed to understand the role that the immunomodulatory cationic...
AB  - We found that hCAP-18/LL-37 was strongly expressed in the stroma of advanced primary and secondary PDAC tumours and is secreted by immune cells of the stroma (eg, tumour-associated macrophages) in response to tumour growth factor-β1 and particularly...
AB  - Thus, hCAP-18/LL-37 represents a previously unrecognised PDAC microenvironment factor that plays a critical role in pancreatic CSC-mediated tumourigenesis.
LA  - eng
PB  - BMJ PUBLISHING GROUP
KW  - ANTIBACTERIAL PEPTIDE
KW  - MACROPHAGES
KW  - PANCREATIC CANCER
KW  - STEM CELLS
TI  - Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.
TY  - research article
ER  -