TY  - JOUR
AU  - Bosch, Marta
AU  - Sanchez-Alvarez, Miguel
AU  - Fajardo, Alba
AU  - Kapetanovic, Ronan
AU  - Steiner, Bernhard
AU  - Dutra, Filipe
AU  - Moreira, Luciana
AU  - Lopez, Juan Antonio
AU  - Campo
AU  - Marí, Montserrat
AU  - Morales-Paytuví, Frederic
AU  - Tort, Olivia
AU  - Gubern, Albert
AU  - Templin, Rachel M
AU  - Curson, James E B
AU  - Martel, Nick
AU  - Català, Cristina
AU  - Lozano, Francisco
AU  - Tebar, Francesc
AU  - Enrich, Carlos
AU  - Vazquez, Jesus
AU  - del Pozo, Miguel Angel
AU  - Sweet, Matthew J
AU  - Bozza, Patricia T
AU  - Gross, Steven P
AU  - Parton, Robert G
AU  - Pol, Albert
PY  - 2020
DO  - 10.1126/science.aay8085
SN  - 0036-8075
UR  - http://hdl.handle.net/20.500.12105/11240
AB  - Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated...
LA  - eng
PB  - American Association for the Advancement of Science (AAAS)
KW  - Immunity, Innate
KW  - Animals
KW  - Antimicrobial Cationic Peptides
KW  - Bacteria
KW  - Fatty Acids
KW  - GTP Phosphohydrolases
KW  - HEK293 Cells
KW  - Host-Pathogen Interactions
KW  - Humans
KW  - Lipid Droplets
KW  - Lipopolysaccharides
KW  - Macrophages
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mitochondria
TI  - Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.
TY  - journal article
ER  -