TY  - GEN
AU  - Pellerino, Alessia
AU  - Priego, Neibla
AU  - Bertero, Luca
AU  - Ricci, Alessia Andrea
AU  - Mangherini, Luca
AU  - Bruno, Francesco
AU  - Beano, Alessandra
AU  - Mittica, Gloria
AU  - Mistrangelo, Marinella
AU  - Garbossa, Diego
AU  - Bosch-Barrera, Joaquim
AU  - Cassoni, Paola
AU  - Valiente, Manuel
AU  - Soffietti, Riccardo
AU  - Rudà, Roberta
PY  - 2025
UR  - https://hdl.handle.net/20.500.12105/27276
AB  - A high pSTAT3 expression in reactive astrocytes surrounding brain metastases (BrM) promotes tumor growth in preclinical models. The impact of STAT3 expression on outcome of patients with BrM from breast cancer is unknown.
AB  - The expression of pSTAT3 in reactive astrocytes of 100 resected BrM from breast cancer was investigated by immunohistochemistry and correlated with molecular subtypes, risk of intracranial recurrence and progression-free survival. To explore whether...
AB  - High pSTAT3 expression in reactive astrocytes was detected in 57% of BrM, and prevailed in triple-negative (80.9%) over HER2-positive (43.2%) and luminal (33.3%) metastases (P = .002). A different pSTAT3 expression was confirmed in animal models: as...
AB  - This study indicates that STAT3 expression prevails in reactive astrocytes surrounding triple-negative BrM in comparison to HER2-positive and luminal BrM, and these findings mirror those observed in animal models. A high STAT3 expression correlates...
LA  - eng
PB  - Oxford
KW  - STAT3 expression
KW  - brain metastases
KW  - breast cancer
KW  - reactive astrocytes
KW  - silibinin
TI  - STAT3 expression in brain metastases from breast cancer is correlated with molecular subtype and impacts clinical outcome.
TY  - research article
ER  -