TY - JOUR AU - Lechuga-Vieco, Ana V. AU - Latorre-Pellicer, Ana AU - Johnston, Iain G AU - Prota, Gennaro AU - Gileadi, Uzi AU - Justo-Mendez, Raquel AU - Acin-Perez, Rebeca AU - Martínez-de-Mena, Raquel AU - Fernandez-Toro, Jose Maria AU - Jimenez-Blasco, Daniel AU - Mora, Alfonso AU - Nicolas-Avila, Jose A. AU - Santiago, Demetrio J AU - Priori, Silvia G. AU - Bolaños, Juan Pedro AU - Sabio, Guadalupe AU - Criado-Rodriguez, Luis M. AU - Ruiz-Cabello, Jesus AU - Cerundolo, Vincenzo AU - Jones, Nick S AU - Enriquez, Jose Antonio PY - 2020 DO - 10.1126/sciadv.aba5345 SN - 2375-2548 UR - http://hdl.handle.net/20.500.12105/11255 AB - Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological... LA - eng PB - American Association for the Advancement of Science (AAAS) TI - Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics. TY - journal article ER -