TY - JOUR AU - Osterloh, Lisa AU - Martínez-Herranz, Raúl AU - Riveiro-Falkenbach, Erica AU - Romero, Pablo-Ortiz AU - Rodríguez-Peralto, José Luis AU - Pastor Fernandez, Joaquin AU - Soengas, MS PY - 2015 DO - 10.18632/oncotarget.4055 UR - http://hdl.handle.net/20.500.12105/10361 AB - Derailed endolysosomal trafficking is emerging as a widespread feature of aggressive neoplasms. However, the oncogenic signals that alter membrane homeostasis and their specific contribution to cancer progression remain unclear. Understanding the... LA - eng PB - Impact Journals KW - ONCOGENE-INDUCED SENESCENCE KW - ENDOPLASMIC-RETICULUM KW - C-MYC KW - RAS KW - TRAFFICKING KW - MUTATIONS KW - AUTOPHAGY KW - BIOGENESIS KW - MECHANISMS KW - EXPRESSION KW - Animals KW - Cell Line, Tumor KW - Fluorescent Antibody Technique KW - Heterografts KW - Humans KW - Immunoblotting KW - Melanoma KW - Mice KW - Microscopy, Electron, Transmission KW - Phosphatidylinositol 3-Kinases KW - Pinocytosis KW - Transfection KW - rab GTP-Binding Proteins KW - ONCOGENE-INDUCED SENESCENCE TI - RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development. TY - journal article ER -