TY - GEN AU - Pinto-Medel, María Jesús AU - Oliver-Martos, Begoña AU - Urbaneja-Romero, Patricia AU - Hurtado-Guerrero, Isaac AU - Ortega-Pinazo, Jesús AU - Serrano-Castro, Pedro AU - Fernández, Óscar AU - Leyva, Laura PY - 2017 DO - 10.1038/s41598-017-09301-2 UR - http://hdl.handle.net/20.500.12105/17328 AB - The alteration of DNA methylation patterns are a key component of disease onset and/or progression. Our objective was to evaluate the differences in Long Interspersed Nuclear Element-1 (LINE-1) methylation levels, as a surrogate marker of global DNA... LA - eng KW - Adult KW - Case-Control Studies KW - DNA Methylation KW - Disease Susceptibility KW - Female KW - Humans KW - Interferon-beta KW - Logistic Models KW - Long Interspersed Nucleotide Elements KW - Male KW - Multiple Sclerosis KW - Multivariate Analysis KW - ROC Curve KW - Reference Standards TI - Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment. TY - research article ER -