TY - JOUR AU - Lechuga-Vieco, Ana Victoria AU - Latorre-Pellicer, Ana AU - Calvo, Enrique AU - Torroja, Carlos AU - Pellico, Juan AU - Acin-Perez, Rebeca AU - García-Gil, María Luisa AU - Santos, Arnoldo AU - Bagwan, Navratan AU - Bonzon-Kulichenko, Elena AU - Magni, Ricardo AU - Benito, Marina AU - Justo-Méndez, Raquel AU - Simon, Anna Katharina AU - Sanchez-Cabo, Fatima AU - Vazquez, Jesus AU - Ruíz-Cabello, Jesús AU - Enriquez, Jose Antonio PY - 2022 DO - 10.1161/CIRCULATIONAHA.121.056286 UR - http://hdl.handle.net/20.500.12105/15225 AB - In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore near-identical, or homoplasmic. The presence... LA - eng PB - American Heart Association (AHA) KW - Frailty KW - Heart Diseases KW - Hypertension, Pulmonary KW - Adult KW - Animals KW - DNA, Mitochondrial KW - Heteroplasmy KW - Humans KW - Mice KW - Mitochondria TI - Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty. TY - journal article ER -