TY  - JOUR
AU  - Kofler, Natalie M
AU  - Cuervo, Henar
AU  - Uh, Minji K
AU  - Murtomäki, Aino
AU  - Kitajewski, Jan
PY  - 2015
DO  - 10.1038/srep16449
UR  - http://hdl.handle.net/20.500.12105/17218
AB  - Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Arteriovenous Malformations
KW  - Blotting, Western
KW  - CADASIL
KW  - Cell Differentiation
KW  - Cells, Cultured
KW  - Disease Models, Animal
KW  - Endothelial Cells
KW  - Gene Expression
KW  - HEK293 Cells
KW  - Humans
KW  - Matrix Metalloproteinase 2
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Microscopy, Confocal
KW  - Microscopy, Electron, Transmission
KW  - Muscle, Smooth, Vascular
KW  - Pericytes
KW  - Receptor, Notch1
KW  - Receptor, Notch3
KW  - Receptor, Platelet-Derived Growth Factor beta
KW  - Receptors, Notch
KW  - Retinal Vessels
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Time Factors
TI  - Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations.
TY  - journal article
ER  -