TY - JOUR AU - Quilichini, Evans AU - Fabre, Mélanie AU - Dirami, Thassadite AU - Stedman, Aline AU - De Vas, Matias AU - Ozguc, Ozge AU - Pasek, Raymond C AU - Cereghini, Silvia AU - Morillon, Lucie AU - Guerra, Carmen AU - Couvelard, Anne AU - Gannon, Maureen AU - Haumaitre, Cécile PY - 2019 DO - 10.1016/j.jcmgh.2019.06.005 SN - 2352345X UR - http://hdl.handle.net/20.500.12105/7837 AB - BACKGROUND AND AIMS: The exocrine pancreas consists of acinar cells that produce digestive enzymes transported to the intestine through a branched ductal epithelium. Chronic pancreatitis is characterized by progressive inflammation, fibrosis and loss... LA - eng KW - Acinar-to-ductal-metaplasia KW - Ducts KW - Hnf1b KW - Pancreatic cancer KW - Pancreatitis TI - Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis TY - journal article ER -