TY - GEN AU - Lopez-Lasanta, Maria AU - Julià, Antonio AU - Maymó, Joan AU - Fernández-Gutierrez, Benjamín AU - Ureña-Garnica, Inmaculada AU - Blanco, Francisco J AU - Cañete, Juan D AU - Alperi-López, Mercedes AU - Olivè, Alex AU - Corominas, Héctor AU - Tornero, Jesus AU - Erra, Alba AU - Almirall, Miriam AU - Palau, Nuria AU - Ortiz, Ana AU - Avila, Gabriela AU - Rodriguez-Rodriguez, Luis AU - Alonso, Arnald AU - Tortosa, Raül AU - Gonzalez-Alvaro, Isidoro AU - Marsal, Sara PY - 2015 DO - 10.1186/s13075-015-0737-8 SN - 1478-6354 UR - http://hdl.handle.net/20.500.12105/17097 AB - INTRODUCTION: Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. This study was performed to investigate the... LA - eng PB - BioMed Central (BMC) KW - Artritis reumatoide KW - Alelos KW - Estudios de cohortes KW - Frecuencia génica KW - Predisposición genética a la enfermedad KW - Genotipo KW - Halotipos KW - Articulaciones KW - Modelos lineales KW - Desequilibrio de ligamiento KW - Metanálisis como asunto KW - Polimorfismo de nucleótido único KW - Receptores de interleucina-6 KW - España KW - Arthritis, Rheumatoid KW - Cohort Studies KW - Gene Frequency KW - Genetic Predisposition to Disease KW - Genotype KW - Haplotypes KW - Humans KW - Joints KW - Linear Models KW - Linkage Disequilibrium KW - Meta-Analysis as Topic KW - Polymorphism, Single Nucleotide KW - Receptors, Interleukin-6 KW - Spain KW - Alleles TI - Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis. TY - research article ER -