TY - JOUR AU - Eguren, Manuel AU - Alvarez Fernandez, Monica AU - García, Fernando AU - López-Contreras, Andrés J AU - Fujimitsu, Kazuyuki AU - Yaguchi, Hiroko AU - Luque-García, José Luis AU - Yamano, Hiroyuki AU - Fernandez-Capetillo, Oscar AU - Malumbres Martinez, Marcos AU - Munoz, Javier PY - 2014 DO - 10.1016/j.celrep.2014.01.017 UR - http://hdl.handle.net/20.500.12105/11399 AB - The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation. Lack of Cdh1 results in structural and numerical chromosome aberrations, a... LA - eng PB - Cell Press KW - Animals KW - Antigens, Neoplasm KW - Binding Sites KW - Cdh1 Proteins KW - DNA Topoisomerases, Type II KW - DNA-Binding Proteins KW - Genomic Instability KW - HEK293 Cells KW - HeLa Cells KW - Humans KW - Kinesin KW - Mice KW - Protein Binding KW - Proteome KW - Pyrimidines KW - Thiones KW - Topoisomerase II Inhibitors KW - Ubiquitination KW - Xenopus TI - A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. TY - journal article ER -