TY  - GEN
AU  - Larramona-Arcas, Raquel
AU  - González-Arias, Candela
AU  - Perea, Gertrudis
AU  - Gutiérrez, Antonia
AU  - Vitorica, Javier
AU  - García-Barrera, Tamara
AU  - Gómez-Ariza, José Luis
AU  - Pascua-Maestro, Raquel
AU  - Ganfornina, María Dolores
AU  - Kara, Eleanna
AU  - Hudry, Eloise
AU  - Martinez-Vicente, Marta
AU  - Vila, Miquel
AU  - Galea, Elena
AU  - Masgrau, Roser
PY  - 2020
DO  - 10.1186/s13024-020-00382-8
UR  - http://hdl.handle.net/20.500.12105/18062
AB  - Background: The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alzheimer's...
LA  - eng
PB  - BioMed Central (BMC)
KW  - APOE4
KW  - Astrocytes
KW  - Calcium signaling
KW  - Sex
KW  - Lysosome
KW  - Purinergic receptors
KW  - Lipidome
KW  - Apolipoproteína E4
KW  - Astrocitos
KW  - Señalización del calcio
KW  - Sexo
KW  - Lisosomas
KW  - Receptores purinérgicos
KW  - Lipidómica
KW  - Alzheimer Disease
KW  - Animals
KW  - Apolipoprotein E3
KW  - Apolipoprotein E4
KW  - Astrocytes
KW  - Calcium
KW  - Cholesterol
KW  - Female
KW  - Hippocampus
KW  - Lysosomes
KW  - Male
KW  - Mice, Transgenic
KW  - Neurons
KW  - Sex
TI  - Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
TY  - research article
ER  -