TY - JOUR AU - Ortega-Molina, Ana AU - Lebrero-Fernández, Cristina AU - Sanz, Alba AU - Calvo-Rubio, Miguel AU - Deleyto-Seldas, Nerea AU - de Prado-Rivas, Lucía AU - Plata-Gómez, Ana Belén AU - Fernández-Florido, Elena AU - González-García, Patricia AU - Vivas-García, Yurena AU - Sánchez García, Elena AU - Graña-Castro, Osvaldo AU - Price, Nathan L AU - Aroca-Crevillén, Alejandra AU - Caleiras, Eduardo AU - Monleón, Daniel AU - Borrás, Consuelo AU - Casanova-Acebes, María AU - de Cabo, Rafael AU - Efeyan, Alejo PY - 2024 DO - 10.1038/s43587-024-00635-x UR - http://hdl.handle.net/20.500.12105/20206 AB - The mechanistic target of rapamycin complex 1 controls cellular anabolism in response to growth factor signaling and to nutrient sufficiency signaled through the Rag GTPases. Inhibition of mTOR reproducibly extends longevity across eukaryotes. Here we... LA - eng PB - Nature Publishing Group TI - A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. TY - journal article ER -