TY - JOUR AU - Nadeem, Taliha AU - Bogue, Wil AU - Bigit, Bianca AU - Cuervo, Henar PY - 2020 DO - 10.1172/jci.insight.125940 UR - http://hdl.handle.net/20.500.12105/17207 AB - Arteriovenous malformations (AVMs) are high-flow lesions directly connecting arteries and veins. In the brain, AVM rupture can cause seizures, stroke, and death. Patients with AVMs exhibit reduced coverage of the vessels by pericytes, the mural cells... LA - eng PB - American Society for Clinical Investigation (ASCI) KW - Animals KW - Arteriovenous Malformations KW - Female KW - Immunoglobulin J Recombination Signal Sequence-Binding Protein KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Myocytes, Smooth Muscle KW - Neovascularization, Pathologic KW - Pericytes KW - Receptors, Notch KW - Retina TI - Deficiency of Notch signaling in pericytes results in arteriovenous malformations. TY - journal article ER -