TY  - JOUR
AU  - Ruiz, Sergio
AU  - Mayor-Ruiz, Cristina
AU  - Lafarga, Vanesa
AU  - Murga, Matilde
AU  - Vega-Sendino, Maria
AU  - Ortega Jimenez, Sagrario
AU  - Fernandez-Capetillo, Oscar
PY  - 2016
DO  - 10.1016/j.molcel.2016.03.006
SN  - 10972765
UR  - http://hdl.handle.net/20.500.12105/8526
AB  - One recurring theme in drug development is to exploit synthetic lethal properties as means to preferentially damage the DNA of cancer cells. We and others have previously developed inhibitors of the ATR kinase, shown to be particularly genotoxic for...
LA  - eng
PB  - Cell Press
KW  - Antineoplastic Agents
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - Cell Cycle Proteins
KW  - Cell Line
KW  - Dose-Response Relationship, Drug
KW  - Drug Resistance, Neoplasm
KW  - Embryonic Stem Cells
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Mitosis
KW  - Molecular Targeted Therapy
KW  - Nuclear Proteins
KW  - Protein Kinase Inhibitors
KW  - Protein-Tyrosine Kinases
KW  - RNA Interference
KW  - Signal Transduction
KW  - Transfection
KW  - cdc25 Phosphatases
KW  - CRISPR-Cas Systems
TI  - A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
TY  - journal article
ER  -