TY - GEN AU - Cidre-Aranaz, Florencia AU - Grünewald, Thomas G P AU - Surdez, D AU - Garcia-Garcia, Laura AU - Carlos Lázaro, J AU - Kirchner, T AU - Gonzalez-Gonzalez, Laura AU - Sastre, A AU - García-Miguel, P AU - López-Pérez, S E AU - Monzon-Fernandez, Sara AU - Delattre, O AU - Alonso, Javier PY - 2017 DO - 10.1038/onc.2016.244 SN - 0950-9232 UR - http://hdl.handle.net/20.500.12105/7805 AB - Ewing sarcoma is characterized by chromosomal translocations fusing the EWS gene with various members of the ETS family of transcription factors, most commonly FLI1. EWS-FLI1 is an aberrant transcription factor driving Ewing sarcoma tumorigenesis by... LA - eng PB - Springer KW - Animals KW - Cell Line, Tumor KW - Female KW - Heterografts KW - Humans KW - MAP Kinase Signaling System KW - Male KW - Membrane Proteins KW - Mice KW - Mice, SCID KW - Oncogene Proteins, Fusion KW - Phosphoproteins KW - Proto-Oncogene Protein c-fli-1 KW - RNA-Binding Protein EWS KW - Sarcoma, Ewing KW - Signal Transduction KW - ras Proteins TI - EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma TY - research article ER -