TY - JOUR AU - Bakiri, Latifa AU - Hamacher, Rainer AU - Graña Castro, Osvaldo AU - Guío-Carrión, Ana AU - Campos Olivas, Ramon AU - Martinez, Lola AU - Dienes, Hans P AU - Thomsen, Martin K AU - Hasenfuss, Sebastian C AU - Wagner, Erwin F PY - 2017 DO - 10.1084/jem.20160935 SN - 0022-1007 UR - http://hdl.handle.net/20.500.12105/8391 AB - Human hepatocellular carcinomas (HCCs), which arise on a background of chronic liver damage and inflammation, express c-Fos, a component of the AP-1 transcription factor. Using mouse models, we show that hepatocyte-specific deletion of c-Fos protects... LA - eng PB - Rockefeller University Press KW - Animals KW - Carcinoma, Hepatocellular KW - Cell Transformation, Neoplastic KW - Cholesterol KW - Diethylnitrosamine KW - Disease Models, Animal KW - Drosophila Proteins KW - Liver KW - Liver Neoplasms KW - Mice KW - Proto-Oncogene Proteins c-fos KW - Repressor Proteins TI - Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation TY - journal article ER -