TY - GEN AU - Aragoneses-Fenoll, Laura AU - Montes-Casado, Maria AU - Ojeda, Gloria AU - García-Paredes, Lucía AU - Arimura, Yutaka AU - Yagi, Junji AU - Dianzani, Umberto AU - Portoles, Pilar AU - Rojo, José M PY - 2021 DO - 10.1002/JLB.2A0220-127R UR - http://hdl.handle.net/20.500.12105/16056 AB - The interaction between the T-lymphocyte costimulatory molecule ICOS and its ligand (ICOS-L) is needed for efficient immune responses, but expression levels are tightly controlled, as altered expression of ICOS or ICOS-L may lead to immunodeficiency,... LA - eng PB - Oxford University Press KW - Costimulation KW - ICOS KW - ICOS-L KW - T Lymphocyte KW - Trans-endocytosis KW - Trogocytosis KW - Animals KW - CHO Cells KW - Cricetinae KW - Cricetulus KW - Down-Regulation KW - Endocytosis KW - Inducible T-Cell Co-Stimulator Ligand KW - Inducible T-Cell Co-Stimulator Protein KW - Lymphocyte Activation KW - Melanoma, Experimental KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout TI - Role of endocytosis and trans-endocytosis in ICOS costimulator-induced downmodulation of the ICOS Ligand TY - research article ER -