TY  - JOUR
AU  - Ferrandiz-Avellano, Maria-Jose
AU  - Martin-Galiano, Antonio Javier
AU  - Arnanz, Cristina
AU  - Camacho-Soguero, Isabel
AU  - Tirado-Velez, JM
AU  - de la Campa, Adela G
PY  - 2016
DO  - 10.1093/nar/gkw602
SN  - 0305-1048
UR  - http://hdl.handle.net/20.500.12105/9487
AB  - We studied the transcriptional response to an increase in DNA supercoiling in Streptococcus pneumoniae by using seconeolitsine, a new topoisomerase I inhibitor. A homeostatic response allowing recovery of supercoiling was observed in cells treated...
LA  - eng
PB  - Oxford University Press
KW  - Benzodioxoles
KW  - DNA
KW  - DNA Topoisomerases, Type I
KW  - DNA, Bacterial
KW  - DNA, Superhelical
KW  - Gene Expression Regulation, Bacterial
KW  - Genes, Bacterial
KW  - Homeostasis
KW  - Microbial Viability
KW  - Phenanthrenes
KW  - Streptococcus pneumoniae
KW  - Transcription, Genetic
KW  - Transcriptome
KW  - Multigene Family
TI  - An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene
TY  - journal article
ER  -