TY - JOUR AU - Sikorra, Stefan AU - Skiba, Martin AU - Dorner, Martin B AU - Weisemann, Jasmin AU - Weil, Mirjam AU - Valdezate, Sylvia AU - Davletov, Bazbek AU - Rummel, Andreas AU - Dorner, Brigitte G AU - Binz, Thomas PY - 2018 DO - 10.3390/toxins10080311 SN - 2072-6651 UR - http://hdl.handle.net/20.500.12105/9796 AB - In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of botulism and represent potential... LA - eng PB - Multidisciplinary Digital Publishing Institute (MDPI) KW - Clostridium botulinum KW - Zn2+ protease KW - Botulinum neurotoxin KW - Serotype F KW - Subtype KW - Synaptobrevin KW - Vesicle associated membrane protein 2 (VAMP-2) KW - Botulinum Toxins KW - Catalysis KW - Peptides KW - Substrate Specificity KW - Vesicle-Associated Membrane Protein 2 TI - Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities TY - journal article ER -