TY  - JOUR
AU  - Jacome, Ariana
AU  - Gutierrez-Martinez, Paula
AU  - Schiavoni, Federica
AU  - Tenaglia, Enrico
AU  - Martinez, Paula
AU  - Rodríguez-Acebes, Sara
AU  - Lecona, Emilio
AU  - Murga, Matilde
AU  - Mendez, Juan
AU  - Blasco, MA
AU  - Fernandez-Capetillo, Oscar
PY  - 2015
DO  - 10.15252/embj.201591829
UR  - http://hdl.handle.net/20.500.12105/19190
AB  - The SMC5/6 complex is the least understood of SMC complexes. In yeast, smc5/6 mutants phenocopy mutations in sgs1, the BLM ortholog that is deficient in Bloom's syndrome (BS). We here show that NSMCE2 (Mms21, in Saccharomyces cerevisiae), an essential...
LA  - eng
PB  - EMBO Press
KW  - Aging
KW  - Animals
KW  - B-Lymphocytes
KW  - Base Sequence
KW  - Cells, Cultured
KW  - Chromosome Segregation
KW  - DNA Breaks, Double-Stranded
KW  - DNA Mutational Analysis
KW  - DNA Replication
KW  - Female
KW  - Haploinsufficiency
KW  - Humans
KW  - Ligases
KW  - Mice, 129 Strain
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Neoplasms
KW  - Protein Transport
KW  - RecQ Helicases
KW  - Sumoylation
KW  - Tumor Suppressor Proteins
KW  - Ubiquitin-Protein Ligases
TI  - NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.
TY  - journal article
ER  -